Journal article

Type VI Secretion System in Pseudomonas aeruginosa SECRETION AND MULTIMERIZATION OF VgrG PROTEINS

Abderrahman Hachani, Nadine S Lossi, Alexander Hamilton, Cerith Jones, Sophie Bleves, David Albesa-Jove, Alain Filloux

JOURNAL OF BIOLOGICAL CHEMISTRY | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2011

Abstract

Pseudomonas aeruginosa is a Gram-negative bacterium causing chronic infections in cystic fibrosis patients. Such infections are associated with an active type VI secretion system (T6SS), which consists of about 15 conserved components, including the AAA+ ATPase, ClpV. The T6SS secretes two categories of proteins, VgrG and Hcp. Hcp is structurally similar to a phage tail tube component, whereas VgrG proteins show similarity to the puncturing device at the tip of the phage tube. In P. aeruginosa, three T6SSs are known. The expression of H1-T6SS genes is controlled by the RetS sensor. Here, 10 vgrG genes were identified in the PAO1 genome, among which three are co-regulated with H1-T6SS, namely..

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University of Melbourne Researchers

Grants

Awarded by Network of Excellence


Awarded by Wellcome Trust


Awarded by Medical Research Council


Awarded by MRC


Funding Acknowledgements

Supported by Network of Excellence Grant "EuroPathoGenomics" LSHB-CT-2005512061-EPG and by Wellcome Trust Grant WT091939.Supported by Medical Research Council Grant G0800171/ID86344.Supported by the Royal Society, Wellcome Trust Grant WT091939 and Medical Research Council Grant G0800171/ID86344.