Journal article

Estradiol for the mitigation of adverse effects of androgen deprivation therapy

Nicholas Russell, Ada Cheung, Mathis Grossmann

Endocrine Related Cancer | BIOSCIENTIFICA LTD | Published : 2017


Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. Conventional endocrine treatment for PCa leads to global sex steroid deprivation. The ensuing severe hypogonadism is associated with well-documented adverse effects. Recently, it has become apparent that many of the biological actions attributed to androgens in men are in fact not direct, but mediated by estradiol. Available evidence supports a primary role for estradiol in vasomotor stability, skeletal maturation and maintenance, and prevention of fat accumulation. Hence there has been interest in revisiting estradiol as a treatment for PCa. Potential roles for estradiol could be in lieu of conventional androgen depr..

View full abstract


Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

N R is supported by an Australian Postgraduate Award. A C is supported by an Endocrine Society of Australia Postdoctoral Award. M G received support from the National Health and Medical Research Council of Australia (NHMRC projects APP1099173, APP1062073, APP1030123).