The role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing
Lihai Zhang, Saeed Miramini, Martin Richardson, Priyan Mendis, Peter Ebeling
AUSTRALASIAN PHYSICAL & ENGINEERING SCIENCES IN MEDICINE | SPRINGER | Published : 2017
With demographic change and increasing life expectancy, osteoporotic fractures have become one of the most prevalent trauma conditions seen in daily clinical practice. A variety of factors are known to affect the rate of healing in osteoporotic conditions (e.g. both biochemical and biomechanical environment of callus cells). However, the influence of impairment of mesenchymal stem cell function in the osteoporotic condition on bone fracture healing has not been fully understood. In the present study, we develop a mathematical model that quantifies the change in biological processes within the fracture callus as a result of osteoporosis. The model includes special features of osteoporosis suc..View full abstract
Awarded by AOTRAUMA Asia Pacific
The authors would like to thank AOTRAUMA Asia Pacific (AOTAP14-02) and Victorian Orthopaedic Research Trust (2015-2016) for their supports.