AIE conjugated polyelectrolytes based on tetraphenylethene for efficient fluorescence imaging and lifetime imaging of living cells

Mengxia Gao; Yuning Hong; Bin Chen; Yinan Wang; Wenjun Zhou; Wallace WH Wong; Jian Zhou; Trevor A Smith; Zujin Zhao

Journal article

AIE conjugated polyelectrolytes based on tetraphenylethene for efficient fluorescence imaging and lifetime imaging of living cells

Mengxia Gao, Yuning Hong, Bin Chen, Yinan Wang, Wenjun Zhou, Wallace WH Wong, Jian Zhou, Trevor A Smith, Zujin Zhao

POLYMER CHEMISTRY | ROYAL SOC CHEMISTRY | Published : 2017

DOI: 10.1039/c7py00564d

Abstract

A series of new conjugated polyelectrolytes (CPEs) containing tetraphenylethene units are synthesized and characterized. They show apparent aggregation-induced emission (AIE) characteristics and give fluorescence covering from cyan to red with high emission efficiencies in aggregates. These AIE CPEs can directly enter and stain living cells for fluorescence imaging with low cytotoxicity, and can provide information on cellular viscosity at different locations based on fluorescence lifetime imaging.

University of Melbourne Researchers

Wallace Wong Author Chemistry

Trevor Smith Author Chemistry

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Grants

Awarded by National Natural Science Foundation of China

Awarded by China Scholarship Council

Awarded by Guangdong Natural Science Funds for Distinguished Young Scholars

Awarded by Scientific Research Fund of Zhejiang Provincial Education Department

Awarded by Zhejiang Provincial Natural Science Foundation of China

Awarded by Fundamental Research Funds for the Central Universities

Funding Acknowledgements

We acknowledge the financial support from the National Natural Science Foundation of China (21404029, 21344007 and 21673082), the China Scholarship Council (201409645002), the Guangdong Natural Science Funds for Distinguished Young Scholars (2014A030306035), the Scientific Research Fund of Zhejiang Provincial Education Department (Y201121319), the Zhejiang Provincial Natural Science Foundation of China (LY14E30009) and the Fundamental Research Funds for the Central Universities (2017ZD001).