Journal article

Multiple Sclerosis: Basic and Clinical

Katherine Buzzard, Wing Hei Chan, Trevor Kilpatrick, Simon Murray, P Beart (ed.), M Robinson (ed.), M Rattray (ed.), NJ Maragakis (ed.)

NEURODEGENERATIVE DISEASES: PATHOLOGY, MECHANISMS, AND POTENTIAL THERAPEUTIC TARGETS | SPRINGER | Published : 2017

Abstract

Multiple sclerosis (MS) is the most common neurodegenerative disease affecting young adults in our community. It is a complex disease influenced by gender, genetic and environmental factors. MS is a chronic inflammatory disease of the central nervous system caused by aberrant immune activation resulting in damage to myelin sheaths within the brain and spinal cord and axonal loss. The demyelinating insult initially impairs the speed and efficiency of nerve cell function. In the majority of cases, this is followed by an innate endogenous repair response that can restore the myelin sheath and nerve cell function to relatively normal levels. However over time and with subsequent demyelinating ev..

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