Journal article
Spontaneous brain activity relates to autonomic arousal
J Fan, P Xu, NT van Dam, T Eilam-Stock, X Gu, YJ Luo, PR Hof
Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2012
Abstract
Although possible sources and functions of the resting-state networks (RSNs) of the brain have been proposed, most evidence relies on circular logic and reverse inference. We propose that autonomic arousal provides an objective index of psychophysiological states during rest that may also function as a driving source of the activity and connectivity of RSNs. Recording blood oxygenation level-dependent (BOLD) signal using functional magnetic resonance imaging and skin conductance simultaneously during rest in human subjects, we found that the spontaneous fluctuations of BOLD signals in key nodes of RSNs are associated with changes in nonspecific skin conductance response, a sensitive psychoph..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
This research was supported by National Institutes of Health Grants R21MH083164 and R01MH094305, and two Research Enhancement Awards from Queens College, City University of New York (to J.F.), Ministry of Science and Technology (973 Program, 2011CB711000) to Y.L., along with the National Center for Research Resources Grant UL1 RR029887 and James S. McDonnell Foundation Grant 22002078 (to P. R. H.). The contents are the sole responsibility of the authors and do not necessarily represent the official views of the aforementioned funding agencies. We thank Michael I. Posner, Evan Thompson, and Richard Bodnar for comments on earlier versions of the manuscript; and Xun Liu, Yunsoo Park, and Kevin Guise for help with data collection.