Journal article

Functional Neural Correlates of Attentional Deficits in Amnestic Mild Cognitive Impairment

Nicholas T Van Dam, Mary Sano, Effie M Mitsis, Hillel T Grossman, Xiaosi Gu, Yunsoo Park, Patrick R Hof, Jin Fan

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

Although amnestic mild cognitive impairment (aMCI; often considered a prodromal phase of Alzheimer's disease, AD) is most recognized by its implications for decline in memory function, research suggests that deficits in attention are present early in aMCI and may be predictive of progression to AD. The present study used functional magnetic resonance imaging to examine differences in the brain during the attention network test between 8 individuals with aMCI and 8 neurologically healthy, demographically matched controls. While there were no significant behavioral differences between groups for the alerting and orienting functions, patients with aMCI showed more activity in neural regions typ..

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Grants

Awarded by National Institute on Aging (of the National Institutes of Health)


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

The present study was funded as a pilot investigation to J.F. by National Institute on Aging (of the National Institutes of Health) grant P50 AG005138 (M.S., Sam Gandy, P.R.H.). Authors J.F., P.R.H., & M.S. conceived the research design. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.