The small molecule that packs a punch: ubiquitin-mediated regulation of RIPK1/FADD/caspase-8 complexes
Rebecca Feltham, John Silke
CELL DEATH AND DIFFERENTIATION | NATURE PUBLISHING GROUP | Published : 2017
The mechanisms that underpin the production of small molecules and cytokines that lead to inflammation or programmed cell death are intricately intertwined. So much so that some of the proteins that contribute to the transcriptional up regulation of cytokines can switch their role in the right circumstances to generate cell death-inducing complexes. This entwinement is reflected in the fact that inflammation helps an organism fight pathogens and that therefore pathogens are under an evolutionary pressure to interfere with this process. Cell death is therefore a defensive measure that may serve to deny pathogens a host cell, expose pathogens to the immune system and also provide additional in..View full abstract
Awarded by National Health and Medical Research Project grant
Rebecca Feltham and John Silke are supported by an National Health and Medical Research Project grant (1081272) and fellowship (1107149), respectively.