Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

MCY Ng; D Shriner; BH Chen; J Li; WM Chen; X Guo; J Liu; SJ Bielinski; LR Yanek; MA Nalls; ME Comeau; LJ Rasmussen-Torvik; RA Jensen; DS Evans; YV Sun; P An; SR Patel; Y Lu; J Long; LL Armstrong; L Wagenknecht; L Yang; BM Snively; ND Palmer; P Mudgal; CD Langefeld; KL Keene; BI Freedman; JC Mychaleckyj; U Nayak; LJ Raffel; MO Goodarzi; YDI Chen; HA Taylor; A Correa; M Sims; DJ Couper; JS Pankow; E Boerwinkle; A Adeyemo; A Doumatey; G Chen; RA Mathias; D Vaidya; AB Singleton; AB Zonderman; RP Igo; JR Sedor; KT Zondervan; EK Kabagambe; DS Siscovick; B McKnight; K Rice; Y Liu; WC Hsueh; W Zhao; LF Bielak; A Kraja; MA Province; EP Bottinger; O Gottesman; Q Cai; W Zheng; WJ Blot; WL Lowe; JA Pacheco; DC Crawford; TP Yang; A Wilk; E Grundberg; S Tsoka; SS Rich; MG Hayes; XO Shu; RJF Loos; IB Borecki; PA Peyser; SR Cummings; BM Psaty; M Fornage; SK Iyengar; MK Evans; DM Becker; WHL Kao; JG Wilson; JI Rotter; MM Sale; S Liu; CN Rotimi; DW Bowden; RC Elston; K Goddard; J Olson; S Ialacci; S Edwards; C Fondran; A Horvath; G Jun; K Kramp; M Slaughter

Journal article

Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes

MCY Ng, D Shriner, BH Chen, J Li, WM Chen, X Guo, J Liu, SJ Bielinski, LR Yanek, MA Nalls, ME Comeau, LJ Rasmussen-Torvik, RA Jensen, DS Evans, YV Sun, P An, SR Patel, Y Lu, J Long, LL Armstrong Show all

Plos Genetics | Published : 2014

DOI: 10.1371/journal.pgen.1004517

Open access

Abstract

Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However, little is known about the genetic risk in African Americans despite the recent identification of more than 70 T2D loci primarily by genome-wide association studies (GWAS) in individuals of European ancestry. In order to investigate the genetic architecture of T2D in African Americans, the MEta-analysis of type 2 DIabetes in African Americans (MEDIA) Consortium examined 17 GWAS on T2D comprising 8,284 cases and 15,543 controls in African Americans in stage 1 analysis. Single nucleotide polymorphisms (SNPs) association analysis was conducted in each study under the additive model after adjustment for age, ..

View full abstract