Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
Matthew J Bown, Gregory T Jones, Seamus C Harrison, Benjamin J Wright, Suzannah Bumpstead, Annette F Baas, Solveig Gretarsdottir, Stephen A Badger, Declan T Bradley, Kevin Burnand, Anne H Child, Rachel E Clough, Gillian Cockerill, Hany Hafez, D Julian A Scott, Simon Futers, Anne Johnson, Soroush Sohrabi, Alberto Smith, Matthew M Thompson Show all
American Journal of Human Genetics | Published : 2011
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10(-5)) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10(-5)). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We co..View full abstract
Awarded by Wellcome Trust
Awarded by Medical Research Council
Awarded by British Heart Foundation