Journal article
An in-depth comparison of the male pediatric and adult urinary proteomes
JW Froehlich, AR Vaezzadeh, M Kirchner, AC Briscoe, O Hofmann, W Hide, H Steen, RS Lee
Biochimica Et Biophysica Acta Proteins and Proteomics | ELSEVIER SCIENCE BV | Published : 2014
Abstract
In this study, we performed an in-depth characterization of the male pediatric infant urinary proteome by parallel proteomic analysis of normal healthy adult (n = 6) and infant (n = 6) males and comparison to available published data. A total of 1584 protein groups were identified. Of these, 708 proteins were identified in samples from both cohorts. Although present in both cohorts, 136 of these common proteins were significantly enriched in urine from adults and 94 proteins were significantly enriched in urine from infants. Using Gene Ontology, we found that the infant-enriched or specific subproteome (743 proteins) had an overrepresentation of proteins that are involved in translation and ..
View full abstractGrants
Awarded by National Institutes of Health
Funding Acknowledgements
We would like to thank the Department of Urology, Boston Children's Hospital/Harvard Medical School, and Dr. Michael Freeman for their continued guidance and support. This study was supported by funding from NIH K08DK077836 (RSL), the Alexander von Humboldt-Foundation (MK), and a Career Development Award from Boston Children's Hospital (RSL). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.