MicroRNA Expression Profile in Human Macrophages in Response to Leishmania major Infection
Julien Lemaire, Ghada Mkannez, Fatma Z Guerfali, Cindy Gustin, Hanene Attia, Rabiaa M Sghaier, Koussay Dellagi, Dhafer Laouini, Patricia Renard
PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2013
BACKGROUND: Leishmania (L.) are intracellular protozoan parasites able to survive and replicate in the hostile phagolysosomal environment of infected macrophages. They cause leishmaniasis, a heterogeneous group of worldwide-distributed affections, representing a paradigm of neglected diseases that are mainly embedded in impoverished populations. To establish successful infection and ensure their own survival, Leishmania have developed sophisticated strategies to subvert the host macrophage responses. Despite a wealth of gained crucial information, these strategies still remain poorly understood. MicroRNAs (miRNAs), an evolutionarily conserved class of endogenous 22-nucleotide non-coding RNAs..View full abstract
Awarded by European Union
Awarded by NIH/NIAID/DMID
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This work was funded by the European Union under its 6th Framework Programme (LSHG-CT-2006-037231) and partially supported by an NIH/NIAID/DMID Grant Number 5P50AI074178 for DL. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.