Integrating Murine Gene Expression Studies to Understand Obstructive Lung Disease Due to Chronic Inhaled Endotoxin
Peggy S Lai, Oliver Hofmann, Rebecca M Baron, Manuela Cernadas, Quanxin Ryan Meng, Herbert S Bresler, David M Brass, Ivana V Yang, David A Schwartz, David C Christiani, Winston Hide
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2013
RATIONALE: Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These obstructive lung diseases have a complex pathophysiology, making them difficult to study comprehensively in the context of endotoxin. Genome-wide gene expression studies have been used to identify a molecular snapshot of the response to environmental exposures. Identification of differentially expressed genes shared across all published murine models of chronic inhaled endotoxin will provide insight into the biology underlying endotoxin-associated lung disease. METHODS: We identified three published murine models with gene exp..View full abstract
Awarded by National Institute of Environmental Health Sciences
Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
Support was provided by ES00002, P30 ES00002, and P01 ES18181 from the National Institute of Environmental Health Sciences for generation of primary microarray data for the Lai and Brass et al studies, Battelle Memorial Institute's Corporate Science & Technology Program for generation of microarray data for the Meng et al study, and F32 ES020082 from the National Institute of Environmental Health Sciences to PL as a career development award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Environmental Health Sciences or the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.