Journal article
Prenatal lead levels, plasma amyloid β levels, and gene expression in young adulthood
M Mazumdar, W Xia, O Hofmann, M Gregas, SH Sui, W Hide, T Yang, HL Needleman, DC Bellinger
Environmental Health Perspectives | US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE | Published : 2012
DOI: 10.1289/ehp.1104474
Abstract
Background: Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD). Objectives: We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempted to assess whether early-life lead exposure was associated with changes in expression of AD-related genes. Methods: We used sandwich enzyme-linked immunosorbent assays (ELISA) to measure plasma concentrations of amyloid β proteins Aβ40 and Aβ42 among 55 adults who had participated as newborns and young children in a prospective cohort study of the effects of lead exposure on ..
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Awarded by National Institute of Environmental Health Sciences (NIEHS)
Awarded by Harvard School of Public Health-NIEHS Center for Environmental Health
Awarded by Harvard Clinical and Translational Science Center (National Institutes of Health)
Funding Acknowledgements
M.M. was supported by K23 ES017437 from the National Institute of Environmental Health Sciences (NIEHS). Additional support was provided by pilot project funding from the Harvard School of Public Health-NIEHS Center for Environmental Health (ES000002), the Annie E. Casey Foundation, the Heinz Foundation, and the Harvard Clinical and Translational Science Center (National Institutes of Health award UL1 RR024758 and financial contributions from Harvard University and its affiliated academic health care centers).