Journal article
Population differences in transcript-regulator expression quantitative trait loci
PR Bushel, R McGovern, L Liu, O Hofmann, A Huda, J Lu, W Hide, X Lin
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Open access
Abstract
Gene expression quantitative trait loci (eQTL) are useful for identifying single nucleotide polymorphisms (SNPs) associated with diseases. At times, a genetic variant may be associated with a master regulator involved in the manifestation of a disease. The downstream target genes of the master regulator are typically co-expressed and share biological function. Therefore, it is practical to screen for eQTLs by identifying SNPs associated with the targets of a transcript-regulator (TR). We used a multivariate regression with the gene expression of known targets of TRs and SNPs to identify TReQTLs in European (CEU) and African (YRI) HapMap populations. A nominal p-value of <1×10 -6 revealed 234..
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Awarded by National Cancer Institute
Funding Acknowledgements
This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH) and National Institute of Environmental Health Sciences (NIEHS) [Z01 ES102345-04] and in part by the National Cancer Institute Grants R37CA76404 and P01CA134294. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.