Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of Myasthenia Gravis
Mandeep Kaur, Sebastian Schmeier, Cameron R MacPherson, Oliver Hofmann, Winston A Hide, Stephen Taylor, Nick Willcox, Vladimir B Bajic
BMC GENOMICS | BMC | Published : 2008
BACKGROUND: About 5% of western populations are afflicted by autoimmune diseases many of which are affected by sex hormones. Autoimmune diseases are complex and involve many genes. Identifying these disease-associated genes contributes to development of more effective therapies. Also, association studies frequently imply genomic regions that contain disease-associated genes but fall short of pinpointing these genes. The identification of disease-associated genes has always been challenging and to date there is no universal and effective method developed. RESULTS: We have developed a method to prioritize disease-associated genes for diseases affected strongly by sex hormones. Our method uses ..View full abstract
Awarded by National Research Foundation
Awarded by DSTNRF Research Chair
MK was supported by the postdoctoral fellowship from Claude Leon Foundation.MK, SS and VBB were supported by the NBN Grants.VBB was partly supported by the National Research Foundation grants (61070, 62302); VBB was partly supported by the DSTNRF Research Chair grant (64751).