Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of Myasthenia Gravis

Abstract

BACKGROUND: About 5% of western populations are afflicted by autoimmune diseases many of which are affected by sex hormones. Autoimmune diseases are complex and involve many genes. Identifying these disease-associated genes contributes to development of more effective therapies. Also, association studies frequently imply genomic regions that contain disease-associated genes but fall short of pinpointing these genes. The identification of disease-associated genes has always been challenging and to date there is no universal and effective method developed. RESULTS: We have developed a method to prioritize disease-associated genes for diseases affected strongly by sex hormones. Our method uses ..