A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus

Grants

Funding Acknowledgements

This work was supported by grants from The National Natural Science Foundation of China (81170386), research foundation of Peking University First Hospital, and the Chinese Scholarship Council (to H.Z.), NIH-MGH Center for Human Immunology Pilot/Feasibility Study Grant (to W.L.), Grants A1082630, and DK078772 (to R.T.C.) from the National Institutes of Health, and U54 A1057159 from NERCE (to R.T.C.), Grant UL1 RR 025758 (to O.H.), and Grant DK088951 from the National Institutes of Health (to L.F.P.).We thank Drs. Nobuyuki Kato and Masanori Ikeda for the gift of the OR6 cell line; Dr. Francis Chisari for the Huh7.5.1 cell line; Dr. Takaji Wakita for the infectious HCV virus JFH1 DNA construct. The SART1 overexpression plasmid was obtained from Prof. Mei Yee Koh (Department of Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, Texas). We would like to acknowledge the superb technical assistance provided by Dr. Caroline Shamu, Su Chiang, Tao Ren, Sean Johnston, Stewart Rudnicki, David Wrobel, and Jen Nale at the ICCB-Longwood screening facility at the Harvard Medical School. The project described was conducted with the support of Harvard Catalyst (The Harvard Clinical and Translational Science Center) (NIH award #UL1 RR 025758 and financial contributions from participating institutions). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.