Genome-wide analysis of cancer/testis gene expression
Oliver Hofmann, Otavia L Caballero, Brian J Stevenson, Yao-Tseng Chen, Tzeela Cohen, Ramon Chua, Christopher A Maher, Sumir Panji, Ulf Schaefer, Adele Kruger, Minna Lehvaslaiho, Piero Carninci, Yoshihide Hayashizaki, C Victor Jongeneel, Andrew JG Simpson, Lloyd J Old, Winston Hide
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2008
Cancer/Testis (CT) genes, normally expressed in germ line cells but also activated in a wide range of cancer types, often encode antigens that are immunogenic in cancer patients, and present potential for use as biomarkers and targets for immunotherapy. Using multiple in silico gene expression analysis technologies, including twice the number of expressed sequence tags used in previous studies, we have performed a comprehensive genome-wide survey of expression for a set of 153 previously described CT genes in normal and cancer expression libraries. We find that although they are generally highly expressed in testis, these genes exhibit heterogeneous gene expression profiles, allowing their c..View full abstract
Awarded by National Institutes of Health Stanford-South African Informatics Training for Global Health
We thank Dmitry Kuznetsov for providing access to the SEREX information on CT genes and Erika Ritter (Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan-Kettering Cancer Center, New York) for providing cell lines. This project was supported by the South African National Bioinformatics Network; National Institutes of Health Stanford-South African Informatics Training for Global Health Grant TW-03-008; Atlantic Philanthropies; The Oppenheimer Memorial Trust; a Research Grant for the RIKEN Genome Exploration Research Project from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese Government (to Y. H.); and a grant from the Genome Network Project from the Ministry of Education, Culture, Sports, Science and Technology, Japan. This work was conducted as part of the Hilton-Ludwig Cancer Metastasis Initiative, funded by the Conrad N. Hilton Foundation and the Ludwig Institute for Cancer Research.