Journal article

Hierarchical disruption in the Bayesian brain: Focal epilepsy and brain networks

Amir Omidvarnia, Mangor Pedersen, Richard E Rosch, Karl J Friston, Graeme D Jackson



In this opinion paper, we describe a combined view of functional and effective brain connectivity along with the free-energy principle for investigating persistent disruptions in brain networks of patients with focal epilepsy. These changes are likely reflected in effective connectivity along the cortical hierarchy and construct the basis of increased local functional connectivity in focal epilepsy. We propose a testable framework based on dynamic causal modelling and functional connectivity analysis with the capacity of explaining commonly observed connectivity changes during interictal periods. We then hypothesise their possible relation with disrupted free-energy minimisation in the Bayes..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Awarded by Wellcome Trust

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (#628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. We also acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility (NIF) at the Florey node and The Victorian Biomedical Imaging Capability (VBIC). GDJ is supported by an NHMRC practitioner's fellowship (#1060312). RER is funded by a Wellcome Trust Clinical Research Fellowship (Ref: 106556/Z/14/Z). KJF is funded by a Wellcome Trust Principal Research Fellowship (Ref: 088130/Z/09/Z).