Journal article
Pioglitazone after ischemic stroke or Transient Ischemic attack
WN Kernan, CM Viscoli, KL Furie, LH Young, SE Inzucchi, M Gorman, PD Guarino, AM Lovejoy, PN Peduzzi, R Conwit, LM Brass, GG Schwartz, HP Adams, L Berger, A Carolei, W Clark, B Coull, GA Ford, D Kleindorfer, JR O'Leary Show all
New England Journal of Medicine | Published : 2016
Abstract
BACKGROUND: Patients with ischemic stroke or transient ischemic attack (TIA) are at increased risk for future cardiovascular events despite current preventive therapies. The identification of insulin resistance as a risk factor for stroke and myocardial infarction raised the possibility that pioglitazone, which improves insulin sensitivity, might benefit patients with cerebrovascular disease. METHODS: In this multicenter, double-blind trial, we randomly assigned 3876 patients who had had a recent ischemic stroke or TIA to receive either pioglitazone (target dose, 45 mg daily) or placebo. Eligible patients did not have diabetes but were found to have insulin resistance on the basis of a score..
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Awarded by National Cancer Institute
Funding Acknowledgements
Supported by a grant (U01NS044876) from the National Institute of Neurological Disorders and Stroke. Pioglitazone and placebo were provided by Takeda Pharmaceuticals International. Dr. Young reports receiving grant support through his institution from Merck and Mifcor; Dr. Inzucchi, receiving fees for serving on advisory boards from Merck, Janssen, Sanofi, Poxel, Boehringer Ingelheim, Eli Lilly, and AstraZeneca, fees for serving on a data monitoring committee from Novo Nordisk and Intarcia, and fees for serving on a steering committee from Lexicon, serving as an expert witness on behalf of Takeda in a patent litigation deposition, and participating in projects for which funding for continuing medical education has been provided to Yale University by Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Abbott, Merck, and Sanofi; Dr. Peduzzi, receiving consulting fees from Millennium; Dr. Schwartz, receiving grant support from Cerenis, Roche, Resverlogix, Sanofi, and the Medicines Company; Dr. Ford, receiving fees for serving on a trial steering committee from Lundbeck, fees for serving on a data safety monitoring board from Cerevast, fees for serving on advisory boards from Pfizer, Athersys, and Daiichi Sankyo, consulting fees from Pfizer, and lecture fees and travel support from AstraZeneca and Boehringer Ingelheim; Dr. Ringleb, receiving fees for serving on advisory boards from Boehringer Ingelheim, Covidien, Bayer, and Daiichi Sankyo and lecture fees and travel support from Boehringer Ingelheim, Bayer, and Daiichi Sankyo; Dr. Spence, receiving consulting and lecture fees from Bayer and Bristol-Myers Squibb, serving as an officer of and having an equity interest in Vascularis, and performing contract research for Bayer, Bristol-Myers Squibb, Pfizer, Acasti Pharma, POM Wonderful, CVRx, AGA Medical, and W.L. Gore. No other potential conflict of interest relevant to this article was reported.