Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
Danni Zheng, Hisatomi Arima, Shoichiro Sato, Antonio Gasparrini, Emma Heeley, Candice Delcourt, Serigne Lo, Yining Huang, Jiguang Wang, Christian Stapf, Thompson Robinson, Pablo Lavados, John Chalmers, Craig S Anderson
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2016
BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale. METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 p..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by Medical Research Council-UK
Awarded by Medical Research Council
The second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial study was supported by Program (571281) and Project (512402 and 1004170) grants from the National Health and Medical Research Council (NHMRC) of Australia (URL: https://www.nhmrc.gov.au). AG was supported by Medical Research Council-UK (Grant ID: MR/M022625/1) (URL: https://www.mrc.ac.uk/). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.