Journal article
Optimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2
H Arima, E Heeley, C Delcourt, Y Hirakawa, X Wang, M Woodward, T Robinson, C Stapf, M Parsons, PM Lavados, Y Huang, J Wang, J Chalmers, CS Anderson
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2015
Abstract
Objectives: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). Methods: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP ,140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP ,180 mm Hg) BPlowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. Results: Analysis of the rando..
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Funding Acknowledgements
The INTERACT2 study was supported by program grant (571281) and project grants (512402 and 1004170) from the National Health and Medical Research Council (NHMRC) of Australia. H.A. holds an Australian Research Council (ARC) Future Fellowship. C.S.A. holds an NHMRC Senior Principal Research Fellowship. All authors had full access to data.