Journal article

Optimal achieved blood pressure in acute intracerebral hemorrhage INTERACT2

Hisatomi Arima, Emma Heeley, Candice Delcourt, Yoichiro Hirakawa, Xia Wang, Mark Woodward, Thompson Robinson, Christian Stapf, Mark Parsons, Pablo M Lavados, Yining Huang, Jiguang Wang, John Chalmers, Craig S Anderson



OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP <140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP <180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. RESULTS: Analysis of the rand..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

The INTERACT2 study was supported by program grant (571281) and project grants (512402 and 1004170) from the National Health and Medical Research Council (NHMRC) of Australia. H.A. holds an Australian Research Council (ARC) Future Fellowship. C.S.A. holds an NHMRC Senior Principal Research Fellowship. All authors had full access to data.