Type-I interferon pathway in neuroinflammation and neurodegeneration: focus on Alzheimer's disease
Juliet M Taylor, Zachery Moore, Myles R Minter, Peter J Crack
JOURNAL OF NEURAL TRANSMISSION | SPRINGER WIEN | Published : 2018
Past research in Alzheimer's disease (AD) has largely been driven by the amyloid hypothesis; the accompanying neuroinflammation seen in AD has been assumed to be consequential and not disease modifying or causative. However, recent data from both clinical and preclinical studies have established that the immune-driven neuroinflammation contributes to AD pathology. Key evidence for the involvement of neuroinflammation in AD includes enhanced microglial and astroglial activation in the brains of AD patients, increased pro-inflammatory cytokine burden in AD brains, and epidemiological evidence that chronic non-steroidal anti-inflammatory drug use prior to disease onset leads to a lower incidenc..View full abstract
This study was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia.