Journal article

Differences in genetic and environmental variation in adult BMI by sex, age, time period, and region: an individual-based pooled analysis of 40 twin cohorts.

Karri Silventoinen, Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon-Mi Hur, Wendy Cozen, Amie E Hwang, Thomas M Mack, Chika Honda, Fujio Inui, Yoshinori Iwatani, Mikio Watanabe, Rie Tomizawa, Kirsi H Pietiläinen, Aila Rissanen, Sisira H Siribaddana, Matthew Hotopf, Athula Sumathipala, Fruhling Rijsdijk, Qihua Tan Show all

American Journal of Clinical Nutrition | Published : 2017

Abstract

Background: Genes and the environment contribute to variation in adult body mass index [BMI (in kg/m2)], but factors modifying these variance components are poorly understood.Objective: We analyzed genetic and environmental variation in BMI between men and women from young adulthood to old age from the 1940s to the 2000s and between cultural-geographic regions representing high (North America and Australia), moderate (Europe), and low (East Asia) prevalence of obesity.Design: We used genetic structural equation modeling to analyze BMI in twins ≥20 y of age from 40 cohorts representing 20 countries (140,379 complete twin pairs).Results: The heritability of BMI decreased from 0.77 (95% CI: 0.7..

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