Signal dependent transport of a membrane cargo from early endosomes to recycling endosomes
Ismail S Mahmoud, Jade Louber, Steve K Dower, Anne M Verhagen, Paul A Gleeson
European Journal of Cell Biology | ELSEVIER GMBH, URBAN & FISCHER VERLAG | Published : 2017
Many membrane cargoes undergo endocytosis and intracellular recycling to the plasma membrane via the early endosomes and the recycling endosomes. However whether specific sorting signals are required for transport from early endosomes to recycling endosomes is not known and the current view is that transport to the recycling endosomes is by a passive default process. Here we show that the cytoplasmic tail of the neonatal Fc receptor (FcRn) contains discrete signals for endocytosis and for sorting to the recycling endosomes. The FcRn cytoplasmic tail has previously been shown to contain the unusual WISL motif for AP2/clathrin-mediated endocytosis. By analysing FcRn mutants and CD8/FcRn chimer..View full abstract
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Awarded by Australian Research Council
This work was supported by funding from the Australian Research Council (LP130100531). ISM was supported by a University of Melbourne International Postgraduate Award.