Functional and neurochemical characterization of angiotensin type 1A receptor-expressing neurons in the nucleus of the solitary tract of the mouse
DA Carter, Y-T Choong, AA Connelly, JK Bassi, NO Hunter, N Thongsepee, IJ Llewellyn-Smith, AY Fong, SJ McDougall, AM Allen
AJP Regulatory Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2017
Angiotensin II acts via two main receptors within the central nervous system, with the type 1A receptor (AT1AR) most widely expressed in adult neurons. Activation of the AT1R in the nucleus of the solitary tract (NTS), the principal nucleus receiving central synapses of viscerosensory afferents, modulates cardiovascular reflexes. Expression of the AT1R occurs in high density within the NTS of most mammals, including humans, but the fundamental electrophysiological and neurochemical characteristics of the AT1AR-expressing NTS neurons are not known. To address this, we have used a transgenic mouse, in which the AT1AR promoter drives expression of green fluorescent protein (GFP). Approximately ..View full abstract
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Awarded by Australian National Health and Medical Research Council
Awarded by Australian Research Council Grant
This work was supported by Australian National Health and Medical Research Council Grants 1007451, 1029396, and 1120477 and Australian Research Council Grant DP1094301. N. Thongsepee was supported by the Faculty of Science Research Fund, Prince of Songkla University.