Journal article

The effect of endothelial cell activation and hypoxia on placental chorionic mesenchymal stem/stromal cell migration

Balta Al-Sowayan, Rosemary J Keogh, Mohammed Abumaree, Harry M Georgiou, Bill Kalionis

PLACENTA | W B SAUNDERS CO LTD | Published : 2017


INTRODUCTION: Chorionic mesenchymal stem/stromal cells (CMSC) can be isolated from the placenta in large numbers. Although their functions are yet to be fully elucidated, they have a role in tissue development and repair. To fulfil such a role, CMSC must be able to migrate to the microenvironment of the injury site. This process is not fully understood and the aim of this study therefore, was to examine in vitro CMSC migration in response to tissue inflammation and hypoxic conditioning. METHODS: CMSC were derived from the chorionic villi. A trans-endothelium migration (TEM) assay was used to study CMSC migration through an activated endothelial cell monolayer using the HMEC-1 cell line. A cy..

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