Journal article

Neonatal basal ganglia and thalamic volumes: very preterm birth and 7-year neurodevelopmental outcomes

Wai Yen Loh, Peter J Anderson, Jeanie LY Cheong, Alicia J Spittle, Jian Chen, Katherine J Lee, Charlotte Molesworth, Terrie E Inder, A Connelly, Lex W Doyle, Deanne K Thompson

PEDIATRIC RESEARCH | NATURE PUBLISHING GROUP | Published : 2017

Abstract

BackgroundThis study aims to (i) compare volumes of individual basal ganglia nuclei (caudate nucleus, pallidum, and putamen) and the thalamus between very preterm (VP) and term-born infants at term-equivalent age; (ii) explore neonatal basal ganglia and thalamic volume relationships with 7-year neurodevelopmental outcomes, and whether these relationships differed between VP and term-born children.Methods210 VP (<30 weeks' gestational age) and 39 term-born (≥37 weeks' gestational age) infants underwent brain magnetic resonance imaging at term-equivalent age, and deep gray matter volumes of interest were automatically generated. 186 VP and 37 term-born children were assessed for a range of neu..

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Grants

Awarded by Australia's National Health & Medical Research Council: Centre for Clinical Research Excellence


Awarded by Centre for Research Excellence


Awarded by National Institutes of Health



Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT


Funding Acknowledgements

This study was supported by Australia's National Health & Medical Research Council: Centre for Clinical Research Excellence 546519 to L.W.D. and P.J.A.; Centre for Research Excellence 1060733 to L.W.D., P.J.A., J.L.Y.C., D.K.T., A.J.S., and W.Y.L.; Project Grants 237117 to L.W.D., 491209 to P.J.A.; Senior Research Fellowship 1081288 to P.J.A.; Career Development Fellowships 1108714 to A.J.S., 1085754 to D.K.T.; Early Career Fellowship 1053787 to J.L.Y.C.. This study was also supported by the National Institutes of Health (HD058056), the Victorian Government's Operational Infrastructure Support Program, and The Royal Children's Hospital Foundation.