Incidental findings on cerebral MRI in twins: the Older Australian Twins Study

R Koncz; A Mohan; L Dawes; A Thalamuthu; M Wright; D Ames; T Lee; J Trollor; W Wen; P Sachdev

Journal article

Incidental findings on cerebral MRI in twins: the Older Australian Twins Study

R Koncz, A Mohan, L Dawes, A Thalamuthu, M Wright, D Ames, T Lee, J Trollor, W Wen, P Sachdev

Brain Imaging and Behavior | SPRINGER | Published : 2018

DOI: 10.1007/s11682-017-9747-2

Abstract

Incidental findings on structural cerebral magnetic resonance imaging (MRI) are common in healthy subjects, and the prevalence increases with age. There is a paucity of data regarding incidental cerebral findings in twins. We examined brain MRI data acquired from community-dwelling older twins to determine the prevalence and concordance of incidental cerebral findings, as well as the associated clinical implications. Participants (n = 400) were drawn from the Older Australian Twins Study. T1-weighted and T2-weighted fluid-attenuated inversion recovery (FLAIR) cerebral MRI scans were systematically reviewed by a trained, blinded clinician. Incidental findings were recorded according to pre-de..

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University of Melbourne Researchers

David Ames Author

Related Projects (1)

GENE-ENVIRONMENT INTERACTION IN HEALTHY BRAIN AGEING AND AGE RELATED NEURODEGENERATION

Healthy ageing is characterised by low level of disability, high cognitive and functional capacity, and an active engagement in life. The mo..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

The Older Australian Twins Study was supported by a National Health and Medical Research Council (NHMRC) / Australian Research Council (ARC) Strategic Award Grant of the Ageing Well, Ageing Productively Program (ID no. 401162). The Australian Twin Registry is supported by a Centre of Research Excellence Grant from the NHMRC administered by the University of Melbourne.