Protective effect of zinc preconditioning against renal ischemia reperfusion injury is dose dependent
Kenny Rao, Kapil Sethi, Joseph Ischia, Luke Gibson, Laurence Galea, Lin Xiao, Mildred Yim, Mike Chang, Nathan Papa, Damien Bolton, Arthur Shulkes, Graham S Baldwin, Oneel Patel
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017
OBJECTIVES: Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury and chronic kidney disease. Two promising preconditioning methods for the kidney, intermittent arterial clamping (IC) and treatment with the hypoxia mimetic cobalt chloride, have never been directly compared. Furthermore, the protective efficacy of the chemically related transition metal Zn2+ against renal IRI is unclear. Although Co2+ ions have been shown to protect the kidney via hypoxia inducible factor (HIF), the effect of Zn2+ ions on the induction of HIF1α, HIF2α and HIF3α has not been investigated previously. MATERIALS AND METHODS: The efficacy of different preconditioning techniques was assessed usi..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was in part supported by the Austin Health Medical Research Foundation (www.austinmrf.org.au). Dr Kapil Sethi was supported by a Foundation for Surgery Research Scholarship from the Australasian Urological Foundation (www.usanz.org.au/auf). Prof Graham Baldwin is supported by a Senior Research Fellowship (1020983) from the National Health and Medical Research Council of Australia (www.nhmrc.gov.au). All the authors confirm that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.