Brain imaging of pain sensitization in patients with knee osteoarthritis
Jesus Pujol, Gerard Martinez-Vilavella, Jone Llorente-Onaindia, Ben J Harrison, Marina Lopez-Sola, Marina Lopez-Ruiz, Laura Blanco-Hinojo, Pere Benito, Joan Deus, Jordi Monfort
PAIN | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
A relevant aspect in osteoarthritic pain is neural sensitization. This phenomenon involves augmented responsiveness to painful stimulation and may entail a clinically worse prognosis. We used functional magnetic resonance imaging (fMRI) to study pain sensitization in patients with knee osteoarthritis. Sixty patients were recruited and pain sensitization was clinically defined on the basis of regional spreading of pain (spreading sensitization) and increased pain response to repeated stimulation (temporal summation). Functional magnetic resonance imaging testing involved assessing brain responses to both pressure and heat stimulation. Thirty-three patients (55%) showed regional pain spreading..View full abstract
Awarded by Catalonia Government
The authors thank the Agency of University and Research Funding Management of the Catalonia Government for their participation in the context of Research Group SGR2014-1673.