Journal article
Synthesis and incorporation of an advanced lipid peroxidation end-product building block into collagen mimetic peptides
I Kavianinia, SH Yang, H Kaur, PWR Harris, RCJ Dobson, AJ Fairbanks, MA Brimble
Chemical Communications | ROYAL SOC CHEMISTRY | Published : 2017
DOI: 10.1039/c7cc05025a
Abstract
Advanced lipid peroxidation end-products (ALEs) accumulate with ageing and oxidative stress-related diseases. Despite their potential therapeutic value, there are no suitably protected ALE building blocks reported in the literature to enable their site-specific incorporation into synthetic peptides. The synthesis of an Fmoc-protected ALE building block, N∈-(3-methylpyridinium)lysine (MP-lysine) and its incorporation into collagen model peptides is reported.
Grants
Awarded by New Zealand Ministry of Business, Innovation and Employment
Funding Acknowledgements
The authors wish to acknowledge funding from the New Zealand Ministry of Business, Innovation and Employment (contract UOCX1208 to RCJD and AJF), the Biomolecular Interaction Centre, and the Maurice Wilkins Centre for Molecular Biodiscovery.