Surfactant phospholipid composition of gastric aspirate samples differs between male and female very preterm infants
Foula Sozo, Noreen Ishak, Risha Bhatia, Peter G Davis, Richard Harding
PEDIATRIC RESEARCH | NATURE PUBLISHING GROUP | Published : 2017
BackgroundAmong preterm infants, males have a greater incidence of respiratory distress and death than do females born at the same gestational age, likely due to sex-related differences in lung maturation. Our aim was to determine whether surfactant phospholipid composition differs between male and female preterm infants.MethodsGastric aspirate samples from male and female infants born between 25 and 30 weeks of gestation at The Royal Women's Hospital, Melbourne, Australia, were collected within 1 h after birth. Phospholipid composition was analyzed by electrospray ionization tandem mass spectrometry.ResultsPreterm males had higher proportions of total phosphatidylinositol (PI) and phosphati..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by a Program Grant from the National Health and Medical Research Council of Australia (ID 606789).