Journal article

Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice

Maarten van den Buuse, Jac Kee Low, Perrin Kwek, Sally Martin, Andrea Gogos



RATIONALE: Altered glutamate NMDA receptor function is implicated in schizophrenia, and gender differences have been demonstrated in this illness. OBJECTIVES: This study aimed to investigate the interaction of gonadal hormones with NMDA receptor-mediated locomotor hyperactivity and PPI disruption in mice. RESULTS: The effect of 0.25 mg/kg of MK-801 on locomotor activity was greater in male mice than in female mice. Gonadectomy (by surgical castration) significantly reduced MK-801-induced hyperlocomotion in male mice, but no effect of gonadectomy was seen in female mice or on amphetamine-induced locomotor hyperactivity. The effect of MK-801 on prepulse inhibition of startle (PPI) was similar ..

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Funding Acknowledgements

These studies were supported by a project grant from the National Health and Medical Research Council (NHMRC) of Australia and Operational Infrastructure Support from the Victorian State Government. MvdB is a Senior Research Fellow and AG was supported by a postdoctoral training fellowship from the NHMRC. None of the funding bodies had any role in the study design, collection, analysis, and interpretation of the data, in the writing of the paper, or the decision to submit it for publication. The authors have no conflict of interest to report.