Ventricular volumes across stages of schizophrenia and other psychoses
Gregor E Berger, Cali F Bartholomeusz, Stephen J Wood, Anthony Ang, Lisa J Phillips, Tina Proffitt, Warrick J Brewer, Deidre J Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R Yung, Patrick D McGorry, Christos Pantelis
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2017
OBJECTIVE: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. METHODS: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). RESULTS: Compared to controls, we identified significant ventricul..View full abstract
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
This study was supported by National Health and Medical Research Council of Australia (NHMRC) Project (209062) and Program Grants (350241, 566529), and by the Colonial Foundation.