Journal article

Ventricular volumes across stages of schizophrenia and other psychoses

Gregor E Berger, Cali F Bartholomeusz, Stephen J Wood, Anthony Ang, Lisa J Phillips, Tina Proffitt, Warrick J Brewer, Deidre J Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R Yung, Patrick D McGorry, Christos Pantelis

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2017

Abstract

OBJECTIVE: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. METHODS: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). RESULTS: Compared to controls, we identified significant ventricul..

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