Ventricular volumes across stages of schizophrenia and other psychoses

Gregor E Berger; Cali F Bartholomeusz; Stephen J Wood; Anthony Ang; Lisa J Phillips; Tina Proffitt; Warrick J Brewer; Deidre J Smith; Barnaby Nelson; Ashleigh Lin; Stefan Borgwardt; Dennis Velakoulis; Alison R Yung; Patrick D McGorry; Christos Pantelis

Journal article

Ventricular volumes across stages of schizophrenia and other psychoses

Gregor E Berger, Cali F Bartholomeusz, Stephen J Wood, Anthony Ang, Lisa J Phillips, Tina Proffitt, Warrick J Brewer, Deidre J Smith, Barnaby Nelson, Ashleigh Lin, Stefan Borgwardt, Dennis Velakoulis, Alison R Yung, Patrick D McGorry, Christos Pantelis

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2017

DOI: 10.1177/0004867417715914

Abstract

OBJECTIVE: Ventricular enlargement is common in established schizophrenia; however, data from ultra high-risk for psychosis and first-episode psychosis studies are inconclusive. This study aims to investigate ventricular volumes at different stages of psychosis. METHODS: Ventricular volumes were measured using a semi-automated and highly reliable method, for 89 established schizophrenia, 162 first-episode psychosis, 135 ultra high-risk for psychosis and 87 healthy controls using 1.5T magnetic resonance images. Clinical outcome diagnoses for ultra high-risk for psychosis were evaluated at long-term follow-up (mean: 7.5 years). RESULTS: Compared to controls, we identified significant ventricul..

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University of Melbourne Researchers

Christos Pantelis Author Psychiatry

Stephen Wood Author Centre for Youth Mental Health

Warrick Brewer Author Centre for Youth Mental Health

Cali Bartholomeusz Author Centre for Youth Mental Health

Patrick McGorry Author Centre for Youth Mental Health

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

This study was supported by National Health and Medical Research Council of Australia (NHMRC) Project (209062) and Program Grants (350241, 566529), and by the Colonial Foundation.