Journal article

The AURORA pilot study for molecular screening of patients with advanced breast cancer-a study of the breast international group

Marion Maetens, David Brown, Alexandre Irrthum, Philippe Aftimos, Giuseppe Viale, Sibylle Loibl, Jean-Francois Laes, Peter J Campbell, Alastair Thompson, Javier Cortes, Sabine Seiler, Sara Vinnicombe, Mafalda Oliveira, Francoise Rothe, Yacine Bareche, Debora Fumagalli, Dimitrios Zardavas, Christine Desmedt, Martine Piccart, Sherene Loi Show all

NPJ BREAST CANCER | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Several studies have demonstrated the feasibility of molecular screening of tumour samples for matching patients with cancer to targeted therapies. However, most of them have been carried out at institutional or national level. Herein, we report on the pilot phase of AURORA (NCT02102165), a European multinational collaborative molecular screening initiative for advanced breast cancer patients. Forty-one patients were prospectively enroled at four participating centres across Europe. Metastatic tumours were biopsied and profiled using an Ion Torrent sequencing platform at a central facility. Sequencing results were obtained for 63% of the patients in real-time with variable turnaround time st..

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Funding Acknowledgements

The authors would like to extend their gratitude to the patients who participated in this study, the BIG HQ, Phuong Dinh and Roberto Salgado for contributing to project set-up and management and to Delphine Vincent and Samira Majjaj for technical assistance. D.B. is supported by the Belgian Fonds National de la Recherche Scientifique (F.R.S.-FNRS). This work was supported by the Breast Cancer Research Foundation (BCRF).