Screening the medicines for malaria venture pathogen box across multiple pathogens reclassifies starting points for open-source drug discovery

Abstract

Open-Access drug discovery provides a substantial resource for diseases primarily affecting the poor and disadvantaged. The open-Access Pathogen Box collection is comprised of compounds with demonstrated biological activity against specific pathogenic organisms. The supply of this resource by the Medicines for Malaria Venture has the potential to provide new chemical starting points for a number of tropical and neglected diseases, through repurposing of these compounds for use in drug discovery campaigns for these additional pathogens. We tested the Pathogen Box against kinetoplastid parasites and malaria life cycle stages in vitro. Consequently, chemical starting points for malaria, human A..