Screening the Medicines for Malaria Venture Pathogen Box across Multiple Pathogens Reclassifies Starting Points for Open-Source Drug Discovery
Sandra Duffy, Melissa L Sykes, Amy J Jones, Todd B Shelper, Moana Simpson, Rebecca Lang, Sally-Ann Poulsen, Brad E Sleebs, Vicky M Avery
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2017
Open-access drug discovery provides a substantial resource for diseases primarily affecting the poor and disadvantaged. The open-access Pathogen Box collection is comprised of compounds with demonstrated biological activity against specific pathogenic organisms. The supply of this resource by the Medicines for Malaria Venture has the potential to provide new chemical starting points for a number of tropical and neglected diseases, through repurposing of these compounds for use in drug discovery campaigns for these additional pathogens. We tested the Pathogen Box against kinetoplastid parasites and malaria life cycle stages in vitro Consequently, chemical starting points for malaria, human Af..View full abstract
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
Awarded by Wellcome Trust
This study was supported by the Australian Research Council (LP120200557 and LP140100560 awarded to V.M.A.), the National Health and Medical Research Council (APP1067728 awarded to V.M.A.), a Wellcome Trust Pathfinder Award (WT109662MA awarded to B.E.S.), and a Victorian State Government Operational Infrastructure Support (B.E.S.). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.