Journal article

Tumor characteristics and family history in relation to mammographic density and breast cancer: The French E3N cohort

Gertraud Maskarinec, Laureen Dartois, Suzette Delaloge, John Hopper, Francoise Clavel-Chapelon, Laura Baglietto



BACKGROUND: Mammographic density is a known heritable risk factor for breast cancer, but reports how tumor characteristics and family history may modify this association are inconsistent. METHODS: Dense and total breast areas were assessed using Cumulus™ from pre-diagnostic mammograms for 820 invasive breast cancer cases and 820 matched controls nested within the French E3N cohort study. To allow comparisons across models, percent mammographic density (PMD) was standardized to the distribution of the controls. Odds ratios (OR) and 95% confidence intervals (CI) of breast cancer risk for mammographic density were estimated by conditional logistic regression while adjusting for age and body mas..

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Funding Acknowledgements

The E3N case-control study was funded by a grant from Fondation ARC pour la recherche sur le cancer (Francoise ClacelChapelon). The E3N cohort was funded by MGEN (Mutuelle Generale de l'Education Nationale) (FCC), Ligue contre le Cancer, Gustave Roussy and Institut National de la Sante et de la Recherche Medicale (Inserm) (FCC). Laura Baglietto was supported by a Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme.