Journal article

Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling

Sam Salman, Francesca Baiwog, Madhu Page-Sharp, Kay Kose, Harin A Karunajeewa, Ivo Mueller, Stephen J Rogerson, Peter M Siba, Kenneth F Ilett, Timothy ME Davis

International Journal of Antimicrobial Agents | ELSEVIER SCIENCE BV | Published : 2017

Abstract

Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women. Such optimised CQ-based regimens, used as treatment for acute malaria or as intermittent preventive treatment in pregnancy (IPTp), may have a valuable role if parasite CQ sensitivity returns following reduced drug pressure. In this study, population pharmacokinetic/pharmacodynamic modelling was used to simultaneously analyse plasma concentration-time data for CQ and its active metabolite desethylchloroquine (DCQ) in 44 non-pregnant and 45 pregnant Papua New Guinean women treated with C..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Practitioner Fellowship


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia [grant 458555] with support and endorsement from the Malaria in Pregnancy (MiP) Consortium, which is funded through a grant from the Bill and Melinda Gates Foundation to the Liverpool School of Tropical Medicine (Liverpool, UK). HAK is supported by an NHMRC Career Development Fellowship (APP1064772) and TMED is supported by a NHMRC Practitioner Fellowship (APP1058260).