Journal article
Host age and expression of genes involved in red blood cell invasion in Plasmodium falciparum field isolates
A Valmaseda, Q Bassat, P Aide, P Cisteró, A Jiménez, A Casellas, S MacHevo, R Aguilar, B Sigaúque, VS Chauhan, C Langer, J Beeson, C Chitnis, PL Alonso, D Gaur, A Mayor
Scientific Reports | NATURE PORTFOLIO | Published : 2017
Abstract
Plasmodium falciparum proteins involved in erythrocyte invasion are main targets of acquired immunity and important vaccine candidates. We hypothesized that anti-parasite immunity acquired upon exposure would limit invasion-related gene (IRG) expression and affect the clinical impact of the infection. 11 IRG transcript levels were measured in P. falciparum isolates by RT-PCR, and IgG/IgM against invasion ligands by Luminex®, in 50 Mozambican adults, 25 children with severe malaria (SM) and 25 with uncomplicated malaria (UM). IRG expression differences among groups and associations between IRG expression and clinical/immunologic parameters were assessed. IRG expression diversity was higher in..
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Awarded by Ministerio de Economia y Competitividad in Spain
Awarded by Instituto de Salud Carlos III [Fondo Europeo de Desarrollo Regional (FEDER)]
Awarded by Department d'Universitats I Recerca de la Generalitat de Catalunya (AGAUR)
Awarded by Instituto de Salud Carlos III
Funding Acknowledgements
Authors would like to thank to the individuals participating in the study and their parents/guardians; the staff of the hospital, clinical officers, field supervisors and data manager; Dr. Ariel Magallon-Tejada, Dr. Himanshu Gupta, Dr. Silvie Huijben, Dr. Mercedes Rubio, Dr. Carlota Dobano and Dr. Alfred Cortes for their useful comments on this project. This work was supported by the Ministerio de Economia y Competitividad in Spain (PRI-PIBIN-2011-0893), the Instituto de Salud Carlos III [grant PI13/01478 2013 call for the Strategic Action on Health 2013-2016 cofunded by the Fondo Europeo de Desarrollo Regional (FEDER), and CES10/021-I3SNS to A.M.]. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya. The Manhica Health Research Centre receives core support from the Spanish Agency for International Cooperation and Development. A.V. received a pre-doctoral fellowship from La Caixa foundation. A.M. is supported by the Department d'Universitats I Recerca de la Generalitat de Catalunya (AGAUR; 2014SGR263).