Journal article

An exposome perspective: Early-life events and immune development in a changing world

Harald Renz, Patrick G Holt, Michael Inouye, Alan C Logan, Susan L Prescott, Peter D Sly

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2017

Abstract

Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system. The result is a transformed view of future prevention and treatment of chronic noncommunicable diseases, including allergy. Paradigm-shifting gains in scientific knowledge are occurring at a time of rapid global environmental change, urbanization, and biodiversity losses. Multifactorial and multigenerational implications of total environmental exposures, the exposome, require coordinated i..

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Grants

Awarded by Heart Foundation


Awarded by Deutsche Zentrum fur Lungenforschung (DZL)


Awarded by Deutsche Forschungsgemeinschaft (DFG)


Funding Acknowledgements

M.I. is supported by a Career Development Fellowship from the Australian NHMRC and Heart Foundation (no. 1061435). H.R. is supported by Deutsche Zentrum fur Lungenforschung (DZL, German Lung Center, no. 82DZL00502) and Deutsche Forschungsgemeinschaft (DFG)-funded SFB 1021.S.L.P. is supported by a Practitioner Fellowship from the Australian NHMRC. P.D.S. is a Senior Principal Research Fellow of the Australian NHMRC.