An exposome perspective: Early-life events and immune development in a changing world
Harald Renz, Patrick G Holt, Michael Inouye, Alan C Logan, Susan L Prescott, Peter D Sly
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | MOSBY-ELSEVIER | Published : 2017
Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system. The result is a transformed view of future prevention and treatment of chronic noncommunicable diseases, including allergy. Paradigm-shifting gains in scientific knowledge are occurring at a time of rapid global environmental change, urbanization, and biodiversity losses. Multifactorial and multigenerational implications of total environmental exposures, the exposome, require coordinated i..View full abstract
Awarded by Heart Foundation
Awarded by Deutsche Zentrum fur Lungenforschung (DZL)
Awarded by Deutsche Forschungsgemeinschaft (DFG)
M.I. is supported by a Career Development Fellowship from the Australian NHMRC and Heart Foundation (no. 1061435). H.R. is supported by Deutsche Zentrum fur Lungenforschung (DZL, German Lung Center, no. 82DZL00502) and Deutsche Forschungsgemeinschaft (DFG)-funded SFB 1021.S.L.P. is supported by a Practitioner Fellowship from the Australian NHMRC. P.D.S. is a Senior Principal Research Fellow of the Australian NHMRC.