Journal article

Dietary Phytochemicals Promote Health by Enhancing Antioxidant Defence in a Pig Model

Sophie NB Selby-Pham, Jeremy J Cottrell, Frank R Dunshea, Ken Ng, Louise E Bennett, Kate S Howell

NUTRIENTS | MDPI | Published : 2017


Phytochemical-rich diets are protective against chronic diseases and mediate their protective effect by regulation of oxidative stress (OS). However, it is proposed that under some circumstances, phytochemicals can promote production of reactive oxygen species (ROS) in vitro, which might drive OS-mediated signalling. Here, we investigated the effects of administering single doses of extracts of red cabbage and grape skin to pigs. Blood samples taken at baseline and 30 min intervals for 4 hours following intake were analyzed by measures of antioxidant status in plasma, including Trolox equivalent antioxidant capacity (TEAC) and glutathione peroxidase (GPx) activity. In addition, dose-dependen..

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Funding Acknowledgements

This project has been funded by Horticulture Innovation Australia Limited using the Vegetable levy and funds from the Australian Government. We gratefully acknowledge the donation of the grape skin extract from Tarac Technologies and assistance during the animal trial by Maree Cox, Shannon Holbrook, Peter Cakebread, Ruslan Pustovit, Udanni Wijesiriwardana, Paula Andrea Giraldo Parra, and Caroline Storer.