Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice
Shijie Liu, Yu Shen, Sandy R Shultz, Nguyen Anne, Christopher Hovens, Paul A Adlard, Ashley I Bush, Jianxiong Chan, Patrick Kwan, Terence J O'Brien, Nigel C Jones
EPILEPSIA | WILEY | Published : 2017
The biologic processes underlying epileptogenesis following a brain insult are not fully understood, but several lines of evidence suggest that hyperphosphorylation of tau may be an important factor in these processes. To provide further insight into the causal relationship between tau and epileptogenesis, this study applied amygdala kindling to rTg4510 mice that, concurrent with other pathologies, overexpress phosphorylated tau, tau knockout mice, or their respective wild-type controls. Mice were electrically stimulated twice daily, 5 days per week for 3 weeks. Electroencephalography was recorded to measure the primary afterdischarge duration, and the behavioral progression of kindling-indu..View full abstract
Related Projects (1)
Awarded by Australian Research Council (ARC) Future Fellowships
Awarded by National Health and Medical Research Council (NHMRC)
PAA (FT120100030) and NCJ (FT13100100) are supported by Australian Research Council (ARC) Future Fellowships. We gratefully acknowledge the support of the Victorian Government's Operational Infrastructure Support Program, and the National Health and Medical Research Council (NHMRC) (project grant APP1006077).