Journal article

How MR1 Presents a Pathogen Metabolic Signature to Mucosal-Associated Invariant T (MAIT) Cells

Hamish EG McWilliam, Jose A Villadangos

TRENDS IN IMMUNOLOGY | ELSEVIER SCI LTD | Published : 2017

Abstract

Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes restricted by the antigen (Ag)-presenting molecule MHC class I (MHC I)-related protein 1 (MR1). The Ags presented by MR1 are vitamin B-related Ags (VitBAgs), 'building-block' metabolites of riboflavin that are synthesized by a range of microbes. MR1 presentation is thus a unique mechanism for the immune detection of a pathogen metabolic signature. While the full picture of how MR1 accomplishes this remains incomplete, recent data show that, unlike other MHC molecules, MR1 operates by a presentation-on-demand mechanism. In the absence of metabolite ligands MR1 is mostly stored in the endoplasmic reticulum (ER). Ligand bin..

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Grants

Funding Acknowledgements

The authors gratefully acknowledge support from the Australian Research Council (DECRA Fellowship, H.E.G.McW.; Discovery Project, J.A.V.), the National Health and Medical Research Council (Program Grant and Fellowship, J.A.V.), and the University of Melbourne (Early Career Researcher Grant, H.E.G.McW.).