Galactose-functionalised PCL nanofibre scaffolds to attenuate inflammatory action of astrocytes in vitro and in vivo
Francesca L Maclean, Chew L Lau, Sam Ozergun, Ross D O'Shea, Cecilia Cederfur, Jason Wang, Kevin E Healy, Frederick R Walker, Doris Tomas, Malcolm K Horne, Philip M Beart, David R Nisbet
JOURNAL OF MATERIALS CHEMISTRY B | ROYAL SOC CHEMISTRY | Published : 2017
Astrocytes represent an attractive therapeutic target for the treatment of traumatic brain injury in the glial scar, which inhibits functional repair and recovery if persistent. Many biomaterial systems have been investigated for neural tissue engineering applications, including electrospun nanofibres, which are a favourable biomaterial as they can mimic the fibrous architecture of the extracellular matrix, and are conveniently modified to present biologically relevant cues to aid in regeneration. Here, we synthesised a novel galactose-presenting polymer, poly(l-lysine)-lactobionic acid (PLL-LBA), for use in layer-by-layer (LbL) functionalisation of poly(ε-caprolactone) (PCL) nanofibres, to ..View full abstract
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Awarded by NHMRC
This research was supported by funding from an NHMRC project grant (APP1020332). FLM was supported by an Australian Postgraduate Award; MKH and PMB were supported by NHMRC Research Fellowships APP1020401 and APP1019833, respectively; DRN was supported by a NHMRC Career Development Fellowship (APP1050684). Access to the facilities of the Australian National University Centre for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged. The Florey Institute of Neuroscience and Mental Health receives infrastructure support from the Victorian State Government (Australia).