Journal article

Relevance of DNA damage repair in the management of prostate cancer

Patricia Banks, Wen Xu, Declan Murphy, Paul James, Shahneen Sandhu

CURRENT PROBLEMS IN CANCER | MOSBY-ELSEVIER | Published : 2017

Abstract

Recent insights into the genomic aberrations that underlie and drive prostate cancer have redoubled efforts to molecularly stratify treatments based on predictive markers. Approximately 23% of patients with metastatic castration-resistant prostate cancer exhibit somatic or germline aberrations in genes implicated in DNA repair, such as BRCA2, BRCA1, ATM, CHEK2, and PALB2, as well as mismatch repair genes. At least 10% of men with advanced disease have germline mutations in DNA-repair genes (DRG). The enrichment of DRG defects in metastatic disease compared with localized, primary tumors suggests a possible role in carcinogenesis, disease progression, and potentially accounts for a more aggre..

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Grants

Awarded by John Mill's Young Investigator Award from Prostate Cancer Foundation of Australia


Funding Acknowledgements

Dr Sandhu is supported by the John Mill's Young Investigator Award from Prostate Cancer Foundation of Australia (Grant No. YI1213)