Journal article
Identical twins doubly exchanged at birth: A case report of genetic and environmental influences on the adult epigenome
NL Segal, YS Montoya, YJ Loke, JM Craig
Epigenomics | FUTURE MEDICINE LTD | Published : 2017
Abstract
Aim: Epigenetic comparisons within monozygotic twin pairs have enhanced our understanding of nongenetic mechanisms underlying disease etiology. We present epigenetic findings for a unique case of doubly exchanged Colombian male monozygotic twins raised in extremely different environments. Results: Using genome-wide DNA methylation data from cheek swabs from which blood-specific differentially methylated probes had been removed, the individuals grouped by shared genetics rather than shared environment, except for one twin who presented as an outlier. Closer inspection of DNA methylation differences within both reared-apart twin pairs revealed several genes and genetic pathways likely to be in..
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Funding Acknowledgements
This study was supported by an intramural research grant and an Open Access Publication Fund Grant to the first author (CSU Fullerton), a book advance to the first two authors (St. Martin's Press, NY, USA) and by the Victorian State Government's Operational Infrastructure Support Program (YJ Loke and JM Craig). The funding bodies had no role in the study design, analysis, data interpretation or writing of this manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.