Journal article

The Probiotics in Pregnancy Study (PiP Study): rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy.

Christine Barthow, Kristin Wickens, Thorsten Stanley, Edwin A Mitchell, Robyn Maude, Peter Abels, Gordon Purdie, Rinki Murphy, Peter Stone, Janice Kang, Fiona Hood, Judy Rowden, Phillipa Barnes, Penny Fitzharris, Jeffrey Craig, Rebecca F Slykerman, Julian Crane

BMC Pregnancy Childbirth | Published : 2016

Abstract

BACKGROUND: Worldwide there is increasing interest in the manipulation of human gut microbiota by the use of probiotic supplements to modify or prevent a range of communicable and non-communicable diseases. Probiotic interventions administered during pregnancy and breastfeeding offer a unique opportunity to influence a range of important maternal and infant outcomes. The aim of the Probiotics in Pregnancy Study (PiP Study) is to assess if supplementation by the probiotic Lactobacillus rhamnosus HN001 administered to women from early pregnancy and while breastfeeding can reduce the rates of infant eczema and atopic sensitisation at 1 year, and maternal gestational diabetes mellitus, bacterial..

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