Journal article

Structural influences on the activity of bismuth(III) indole-carboxylato complexes towards Helicobacter pylori and Leishmania

Amita Pathak, Victoria L Blair, Richard L Ferrero, Lukasz Kedzierski, Philip C Andrews

JOURNAL OF INORGANIC BIOCHEMISTRY | ELSEVIER SCIENCE INC | Published : 2017

Abstract

Seven new bismuth(III) complexes derived from indole-carboxylic acids have been synthesised: five are homoleptic; [Bi(IAA)3] B1, [Bi(IPA)3] B2, [Bi(IBA)3] B3, [Bi(MICA)3] B4, [Bi(IGA)3] B6, and two are heteroleptic [BiPh(MICA)2] B5 (where IAA-H=2-(1H-indol-3-yl)acetic acid, IPA-H=3-(1H-indol-3-yl)propanoic acid, IBA-H=4-(1H-indol-3-yl)butanoic acid, IGA-H=2-(1H-indol-3-yl)-2-oxoacetic acid, and MICA-H=1-methyl-1H-indole-3-carboxylic acid). All complexes were fully characterised by elemental analysis, infrared and mass-spectroscopy, and nuclear magnetic resonance (1H, 13C) spectroscopy. Complex [BiPh(IGA)2] B7 is structurally authenticated by X-ray crystallography as a dimer in the solid-stat..

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Grants

Awarded by Australian Research Council


Awarded by NHMRC, Australia


Awarded by NHMRC IRIISS grant


Awarded by Senior Research Fellowship from the National Health and Medical Research Council


Funding Acknowledgements

We thank the Australian Research Council (DP110103812) and Monash University for financial support. LK was supported by the NHMRC, Australia (project grant #1023559), an NHMRC IRIISS grant 361646 and a Victorian State Government Operational Infrastructure Scheme grant. RLF is supported by a Senior Research Fellowship from the National Health and Medical Research Council (APP1079904). Research at the Hudson Institute is supported by the Victorian Government's Operational Infrastructure Support Program.