Homoleptic and Heteroleptic Bismuth(III) Thiazole-Thiolates and the Influence of Ring Substitution on Their Antibacterial and Antileishmanial Activity
Ahmad Luqman, Victoria L Blair, Rajini Brammananth, Paul K Crellin, Ross L Coppel, Lukasz Kedzierski, Philip C Andrews
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | WILEY-V C H VERLAG GMBH | Published : 2015
Two new homo- and heteroleptic bismuth thiazole-thiolato complexes derived from 4-phenylthiazole-2-thiol MBT(H) have been synthesised and structurally characterised, [BiPh(MBT)2]2 and [Bi(MBT)3]2. Syntheses were achieved using BiPh3 or Bi(OtBu)3 in protolysis reactions with MBT(H), or by salt metathesis with BiCl3 or BiPhCl2 and the sodium thiolate, [NaMBT]. The complexes were obtained under both standard solvent-free and solvent-mediated conditions, and by microwave irradiation. The solid-state structures of [BiPh(MBT)2]2 and [Bi(MBT)3]2, were determined using single-crystal X-ray diffraction, showing them to be dimeric. The bactericidal properties of the complexes against Mycobacterium sme..View full abstract
Awarded by Australian Research Council
The authors thank Monash University and the Australian Research Council (DP110103812) for financial support. The authors also wish to thank Associate Professor Benjamin Howden (Austin Health) for supplying the MRSA and VRE strains for antimicrobial activity testing and Charles Ma for culturing the COS-7 cells.